Single cell RNA sequencing analyses showed the increased presence of dysfunctional neutrophils expressing S100A8, S100A9, DEFA3 and DEFA4 genes in the PBMCs of severe COVID-19 patients suggesting association of the phenotypic alterations in neutrophils with disease severity (Schulte-Schrepping et al., 2020). The gene discussed is DEFA4; the disease is COVID-19.