Several studies have already correlated higher iNOS (Sasaki et al., 1998; Chakravortty and Hensel, 2003) and ROS levels (Fang, 2011; Gogoi et al., 2019) with reduced bacterial infection and further, it has been demonstrated that iNOS plays a pivotal role in determining the infection outcome in senescent cells (Fernandes et al., 2021). This evidence concerns the gene NOS2 and bacterial infectious disease.