Analysis of the effect of HIST1H1B expression on breast cancer cell migration and invasion showed that HIST1H1B expression led to significant increase in the migration and invasion of SUM159, BT549 and Hs578T cells, whereas knockdown of HIST1H1B expression markedly repressed the migration and invasion of MDA-468 and BT20 Cells (Figures 3C, D). Here, H1-5 is linked to breast cancer.