We have identified several factors that might predict patient prognosis, including (1) Breast cancer subtypes: HIST1H1B expression is elevated in BLBC; (2) Tumor size: HIST1H1B overexpression is associated with larger tumor size; (3) Tumor grade: HIST1H1B overexpression is correlated with higher tumor grade; (4) Tumor metastasis: HIST1H1B overexpression has a significantly higher probability of metastasis; (5) Survival rate: HIST1H1B overexpression predicts poor survival in breast cancer patients. This evidence concerns the gene H1-5 and breast cancer.