Importantly, forced expression of miR-206 could enhance the sensitivity of cervical cancer cells to CDDP through targeting oncogene CCND2. Furthermore, our results showed that lncRNA OTUD6B-AS1 promotes CDDP resistance in cervical cancer cells by up-regulating CCND2 expression via sequestering miR-206. The gene discussed is CCND2; the disease is cervical carcinoma.