The ratio of CD20+ to CD3+ T cells was similar between the ICI+/met+ and ICI-/met+ patients (0.24 vs. 0.23 CD20+ T cells per CD3+ T cell), while the ratio of CD4+ to CD8+ T cells was numerically lower in patients with ICI–met-induced neutropenia (ICI+/met+) than in patients with non-ICI met-induced neutropenia (ICI-/met+) (median 0.68 vs. 0.8 CD4+ T cells per CD8+ T cell, Supplemental Figure 1). The gene discussed is CD4; the disease is Decreased total neutrophil count.