APOE and non-small cell lung carcinoma: By assessing tumor-infiltrating myeloid cells (TIMs) in patients with non-small-cell lung cancer (NSCLC) using scRNA-seq, 25 TIM-specific genes, such as TREM2, CD81, MARCO, and APOE, were consistently identified, and their expression in bone marrow cells from different species was extremely heterogeneous (29, 30).