Based on the Illumina Human Beadchip 27K array, sphingomyelin phosphodiesterase 3 (SMPD3) and neurofilament, heavy polypeptide (NEFH) were found to behave as tumor suppressor genes in HCC after validation in vitro and in vivo (33). This evidence concerns the gene SMPD3 and hepatocellular carcinoma.