13.8% of 297 cervical squamous cell carcinoma cases revealed that genetic alterations in the five-gene signature with a low frequency of ALDH1A2 (1.3%), OSR2 (1%), GRIA4 (4%), GATA4 (1%), and IRX4 (7%) (Figure 1C). The gene discussed is OSR2; the disease is cervical squamous cell carcinoma.