Several studies have investigated the sensitivity and specificity of the pan-Trk IHC method versus the FISH or NGS method, and the results showed that the positive and negative predictive values are high between the various methods, in infant fibrosarcoma, lipofibromatosis-like neural tumor, colorectal cancer, and lung adenocarcinoma. The gene discussed is NTRK1; the disease is lung adenocarcinoma.