ESR1 and breast cancer: It is noteworthy that LINC00511 expression levels are strongly associated with BC disease aggressiveness, being expressed more in the advanced histologic grade (III/IV), positive ER/PR, positive LNM, and tumor size > 2 cm by 2.15-, 1.70-, 1.85-, 6.31-, and 5.32-fold, respectively (Table 5).