In contrast, genes located in deletion regions among the LS patients were significantly enriched in immune-related processes, such as “RIG-I-like receptor signaling pathway”, “natural killer cell mediated cytotoxicity”, “Toll-like receptor signaling pathway”, “cytokine-cytokine receptor interaction” and “JAK-STAT signaling pathway”, indicating a functional deficiency of the immune system in the late stage of LUAD (Supplementary Figure S6D). This evidence concerns the gene SOAT1 and Leigh syndrome.