The eHCC patients were characterized by the type of dysregulated immune cells and presented variable association with different cluster types; Cluster C1 signature showed negative association with activated CD8 T cell (CD8 Tam), Effector memory CD8 T cell (CD8 Tem), and cytotoxic T cell (CTL) infiltration levels in eHCC and aHCC groups and simultaneously presented positive correlation in non-tumor group; Cluster C3 signature showed positive association with CD8 Tam, CD8 Tem, and CTL infiltration levels in eHCC, aHCC, and non-tumor groups (Figure 4C). The gene discussed is CD8A; the disease is neoplasm.