A study of 11 gastric cancer cell lines demonstrated that IGFBP1 expression levels were extremely low in all cell lines, whereas IGFBP2 and IGFBP4 were expressed in 10 and 9 cell lines, respectively, and IGFBP3, IGFBP5, and IGFBP6 were expressed in half of all cell lines (25). Here, IGFBP6 is linked to gastric cancer.