Figure 7B shows some examples of specific correlations of IGFBP with CAFs in STAD. These results further indicate that IGFBP3–7 have important roles in the TME. The correlation of IGFBP expression and other subtypes of immune cell infiltration including B cells, CD4+T cells, CD8+T cells, neutrophils, macrophages, and dendritic cells in patients with gastric cancer is shown in Supplementary Figure 4. This evidence concerns the gene CD4 and gastric cancer.