IGFBP7 is upregulated in gastric cancer and located in the cytoplasm of the majority of cancer cells, fibroblasts, and lymphocytes, and its expression is significantly correlated with indicators of pathological stage including tumor invasion depth, lymph node metastasis, and distant metastasis/recurrence (29). The gene discussed is IGFBP7; the disease is metastatic malignant neoplasm in the lymph nodes.