Using the EPIC, MCPCOUNTER, XCELL, and TIDE algorithms, we found that IGFBP3/4/5/6/7 were all associated with cancer-associated fibroblast (CAF) infiltration in STAD, COAD (colon adenocarcinoma), and READ (rectal adenocarcinoma) (Figure 7A). The gene discussed is IGFBP3; the disease is rectum adenocarcinoma.