The puzzled question is that activation of cGMP/PKG signaling induces MST/LATS kinases, resulting in the phosphorylation and cytosolic degradation of YAP1 in prostate cancer cells (53), while HPV16 E6 has been showed to have little or no effect on the LATS1/2 (49). The gene discussed is PRKG1; the disease is Familial prostate cancer.