In conclusion, peptides and proteins (e.g., SHPRH-146aa, FBXW7-185aa, PINT-87aa, AKT3-174aa, circ-E-cad, rtEGFR) that encoded by circRNAs play an important role in glioma progression by modulating metabolic reprogramming, the epithelial mesenchymal transition (EMT) transition and the stability of oncogenic proteins (e.g., c-Myc). The gene discussed is AKT3; the disease is glioma.