For example, circ-FBXW7 is downregulated in glioma and a cross‐linked ORF in circ-FBXW7, which is formed by the covalent connection of exon 3 and exon 4 of the FBXW7 gene, encodes a novel 21-kDa protein called FBXW7-185aa in an IRES-driven manner (107). Here, FBXW7 is linked to glioma.