Moreover, circCPA4, circPITX1, circPRKCI, circ_001350 and circHECTD1 are significantly upregulated in glioma and accelerate glioma cell aggressiveness via the let7/CPA4, miR-518a-5p/IL17RD, miR-545, miR-1236 and miR-296-3p axes (60, 69, 70, 142, 143). The gene discussed is IL17RD; the disease is central nervous system cancer.