Some other circRNAs (e.g., circEPHB4, circCPA4, circ-MAPK4, circ-POSTN, circNFIX, circSCAF11, circ-U2AF1 and circLGMN are also associated with poor patient prognosis in glioma (44, 52, 54, 56, 60, 62, 73, 83). This evidence concerns the gene MAPK4 and central nervous system cancer.