Notably, a recent study demonstrated that the tumor suppressor gene E-cadherin could be cyclized to form circ-E-Cad in an IRES-driven manner, and circ-E-Cad could encode a 254-amino-acid protein called circRNA-encoded E-cadherin (C-E-Cad), this protein activates the epidermal growth factor receptor (EGFR) in an autocrine/paracrine fashion. The gene discussed is EGFR; the disease is neoplasm.