KLF3 and neoplasm: Moreover, the KLF3-AS1 and miR-223 expression levels in the dissected tumor tissues were examined by qRT-PCR, and the results showed that KLF3-AS1 was significantly up-regulated, and miR-223 was significantly down-regulated in the pcDNA3.1-KLF3-AS1 group when compared to the pcDNA3.1 group (Figures 6C, D).