LMTK3 also functioned at distal regions in tethering the chromatin to the nuclear periphery resulting in H3K9me3 modification and tumor suppressor like-gene silencing (23); therefore, knockdown of LMTK3 may also inhibit the growth of Ishikawa cells through other ERα independent mechanisms, which needs further studies. The gene discussed is LMTK3; the disease is neoplasm.