As shown in Figure 1, the bands of AQP3 were seen in normal skin tissues (NST), solar keratosis (SoK), seborrheic keratosis (SbK), eccrine poroma (EP), sebaceoma (SB), squamous cell carcinoma (SCC), Bowen's disease (BD), and apocrine carcinoma (AC) but not expressed in nevocellular nevus (NN), basal cell carcinoma (BC), and malignant melanoma (MM). This evidence concerns the gene AQP3 and squamous cell carcinoma.