EZH2 is a highly maintained histone methyltransferase (HMTase) which is capable of stimulating H3K27me3 as well as inhibiting transcription and secretion of target genes mediating several fundamental biological processes such as cell cycle modulation, cell fate assessment, senescence, cell proliferation, differentiation, apoptosis, and glioma progression [16, 17, 22]. The gene discussed is EZH2; the disease is glioma.