EZH2 oversecretion was implicated in the malfunction of several fundamental signaling pathways like the wingless-related integration site (Wnt)/β-catenin signaling, rat sarcoma (Ras) and NF-κB signaling pathways, PI3K/AKT pathway, β-adrenergic receptor signaling, and bone morphogenetic protein (BMP) as well as NOTCH signaling pathways in cancers [16, 96–99]. This evidence concerns the gene AKT1 and cancer.