EZH2 is a highly maintained histone methyltransferase (HMTase) which is capable of stimulating H3K27me3 as well as inhibiting transcription and secretion of target genes mediating several fundamental biological processes such as cell cycle modulation, cell fate assessment, senescence, cell proliferation, differentiation, apoptosis, and glioma progression [16, 17, 22]. Here, EZH2 is linked to central nervous system cancer.