EZH2 and neoplasm: Thus, AKT-STAT3-EZH2 signaling and EZH2 phosphorylation participated in cancer stem cell (CSC) growth as well as carcinogenesis, and administration of melatonin blocked EZH2 S21 phosphorylation as well as EZH2-STAT3 intercommunications and modulated histone modifications resulting in the blockade of tumor initiation as well as propagation [107].