Protein kinase B (PKB)/AKT-induced pS21 EZH2 was capable of accelerating EZH2-STAT3 intercommunication (Figure 1), stimulated EZH2-mediated STAT3 methylation, and augmented STAT3 activity in glioblastoma multiforme (GBM) stem-like cells (GSCs) [64]. The gene discussed is AKT1; the disease is glioblastoma.