AKT-stimulated pS21 EZH2 was capable of accelerating EZH2-STAT3 intercommunication and augmenting EZH2-mediated methylation as well as activities of STAT3 resulting in the facilitation of GSC self-renewal as well as GBM tumor progression (Figure 2) [38]. The gene discussed is EZH2; the disease is glioblastoma.