The ten common genes in the subcoeruleus nucleus areGLYAT, HCN4, HMGB1 HNRNPU, ITGB2,LAMP2, LOC653110, OPA3, ,PHTF2, and SLC6A6, , among which the relevant ones to this study areHNRNPU, which as mentioned above is involved in circadian regulation of gene expression and insulin signaling,ITGB2, which is associated with PD and IR, andHMGB1, which is a ligand for the RAGE receptor. This evidence concerns the gene OPA3 and Parkinson disease.