A comparison of the shared gene correlates for sleep, neurodegeneration, behavior, and insulin led to the identification of genes such asAGER,BHLHE41, CACNA1C, CAMK1D, andHMGB1, whose defects might be plausible for the narcoleptic-like symptoms in PD and the relationship with IR. The gene discussed is CACNA1C; the disease is Parkinson disease.