Notably, aerobic exercise or genetic knockout of lysocardiolipin acyltransferase 1 (ALCAT1) activates the aforementioned AMPK-PGC1-α-irisin signaling cascade, thereby alleviating the oxidative stress-triggered mitochondrial dysfunction and cell apoptosis in kidneys of mice with myocardial infarction [127]. The gene discussed is FNDC5; the disease is myocardial infarction.