After the adjustment of all the covariates (model 3), such as age, gender, BMI, educational level, hypertension, vitamin E, and CRP levels, serum 25(OH)D deficiency (OR: 1.770, 95% CI: 1.023-3.065, and P = 0.034) was still the independent risk factors for stroke. The gene discussed is CRP; the disease is hypertensive disorder.