Nevertheless, while FHL2 knockouts displayed greater cardiac hypertrophy following catecholamine stimulation (Kong et al. 2001), global loss of the protein is well tolerated, and the hypertrophic response following transverse-aortic constriction (TAC) was indistinguishable from that of controls (Chu et al. 2000a). The gene discussed is FHL2; the disease is cardiac hypertrophy.