FHL2 and cancer: Pathway enrichment analysis for the over 200 known binding partners for FHL2 catalogued in the protein interaction database BioGrid (Stark et al. 2006) suggests roles for FHL2 in cancer (diseases in signal transduction and second messengers); Smad, Notch and Wnt signaling; and functions for the protein in regulating transcription factor activity that are also supported by its shuttling to the nucleus in many cell-types (Genini et al. 1997; Huang et al. 2019; Labalette et al. 2004; Scholl et al. 2000; Wei et al. 2003).