FHL1 exhibits baseline expression levels in many tissues and becomes specifically upregulated in the heart of many cardiomyopathy models, including MHC403+/ mice (Christodoulou et al. 2014), MLP knockouts (Chu et al. 2000b), Gαq and Gsα transgenic mice (Gaussin et al. 2003; Sheikh et al. 2008), as well as in cardiomyopathy patients (Christodoulou et al. 2014). The gene discussed is GNAS; the disease is cardiomyopathy.