FHL1 is also upregulated in mouse models of cardiomyopathy induced by myosin heavy chain missense mutations (MHC403/+) (Christodoulou et al. 2014), MLP deletion (Chu et al. 2000b), in Gαq and Gsα transgenic mice (Gaussin et al. 2003; Sheikh et al. 2008) as well as mice that overexpress β-adrenergic receptors (Gaussin et al. 2003). This evidence concerns the gene GNAS and cardiomyopathy.