However, in α-myosin heavy chain R403Q missense mutation mice (MHC403/+), another mouse model for hypertrophic cardiomyopathy with elevated levels of FHL1, ablation of the gene had opposing effects and exacerbated the cardiomyopathy phenotype (Christodoulou et al. 2014). This evidence concerns the gene FHL1 and hypertrophic cardiomyopathy.