For instance, a functional readout has been developed to study TnT mutations leading to HCM or DCM (Pettinato et al. 2020), RBM20 therapy has been validated in a DCM model (Briganti et al. 2020), and disruption of SRX state has been linked to hypercontractility in cells harboring a MYH7 mutation (Vander Roest et al. 2021). Here, MYH7 is linked to familial dilated cardiomyopathy.