In fact, DCM mutations in MYH7 reduce myosin ATPase activity and motor function (Schmitt et al. 2006), while DCM mutations in thin-filament proteins decrease myofibril calcium sensitivity, resulting in reduced tension and faster relaxation (Robinson et al. 2007; Gangadharan et al. 2017). The gene discussed is MYH7; the disease is familial dilated cardiomyopathy.