In particular, missplicing of the RBM20-target calcium/calmodulin-dependent protein kinase II (CaMKII), a crucial modulator of E-C coupling in cardiomyocytes (Maier and Bers 2007), is likely responsible for altered cellular calcium handling and cellular calcium overload observed in RBM20 cardiomyopathy (van den Hoogenhof et al. 2018). Here, RBM20 is linked to cardiomyopathy.