In addition, the role of circadian clock genes in cancer-related signaling pathways, including TSC/mTOR, RTK, RAS/MAPK, PI3K/AKT, hormone ER, hormone AR, EMT, DNA damage response, cell cycle, and apoptosis pathways, were examined (Figures 8(a) and 8(b)). The gene discussed is AKT1; the disease is cancer.