Olmesartan is a selective AT1R antagonist, which blocks the vasoconstrictive effect of AT1R by selectively blocking the binding of AT1R and vascular smooth muscle AT1R. In an effort to explore whether AT1R level affects the prognosis of ischemic stroke patients with hypertension, this study divided patients into a high-AT1R group and low-AT1R group based on their plasma AT1R level before treatment. This evidence concerns the gene AGTR1 and ischemic stroke.