IL1B and Sepsis: Liriodendrin (15) was reported to exhibit protective role in sepsis-induced acute lung injury via diminishing the release of many proinflammatory mediators, viz. TNF-α, IL-1β, MCP-1, and IL-6 and lung myeloperoxidase accumulation in addition to suppressing the VEGF expression and NF-κB activation in the lung [46].