According to the results of our analysis, neuroactive ligand-receptor interaction, cAMP signaling pathway, and one of the key pathways to treat insomnia in ZSS, in the pathway, multiple targets such as ADRA1A, ADRA1B, and ADRA1D can be simultaneously regulated by components such as (S)-cointeraction, sanjoinenine, and zizyphusine, and upregulation of neuroactive ligand-receptor interaction has also been an active process for the treatment of insomnia [35]. This evidence concerns the gene ADRA1D and insomnia.