IGHE and allergic disease: However, Caca and Cooke proposed in 1923 the “atopic constitution” that is prone to hypersensitivity reactions due to high IgE levels [9, 10]; it is very similar to the allergic constitution proposed by Chinese medicine; and Wollenberg, Thomsen, and Lazarewicz believed that the specific IgE in people with allergies is relatively high [11].