WNK2 and glomerulosclerosis: Active oxygen can activate phosphatidylinositol signaling pathway and mitogen-activated protein kinase signaling pathway, so that nuclear factor-κB and activator protein 1 are phosphorylated and activated, and then regulate the transcription of corresponding genes, resulting in the increase of growth factors and extracellular matrix, and finally the formation of glomerulosclerosis and renal function injury take place.