In order to investigate whether CR and MOR play a role in LPD alleviate CG by changing the disease targets through acting on different target proteins in TNF signaling pathway, we measured the expressions of p-MKK6, MKK6, RIP, p-p38, and p38 by ELISA and western blotting. The gene discussed is MAPK14; the disease is disseminated peritoneal leiomyomatosis.