HMGA1 and EIF4EBP1 were upregulated hub genes, and DUSP1, JUN, EGR2, KAT2B, PER2, CRY2, TEF, WASF3, KDR, RRAGD, EZH1, and CBX7 were downregulated hub genes in BC. Here, HMGA1 is linked to breast cancer.