HMGA1 and EIF4EBP1 were upregulated hub genes, and DUSP1, JUN, EGR2, KAT2B, PER2, CRY2, TEF, WASF3, KDR, RRAGD, EZH1, and CBX7 were downregulated hub genes in BC. The gene discussed is CBX7; the disease is breast cancer.