HMGA1 and EIF4EBP1 were upregulated hub genes, and DUSP1, JUN, EGR2, KAT2B, PER2, CRY2, TEF, WASF3, KDR, RRAGD, EZH1, and CBX7 were downregulated hub genes in BC. This evidence concerns the gene PER2 and breast cancer.