There were statistically significant differences in CSF leak, epidural hematoma, ventricular hemorrhage, subdural fluid accumulation, tSAH, CSF protein level, FIM score, and the levels of NGF, ACTH, and AVP in the CSF between the communicating hydrocephalus group and the noncommunicating hydrocephalus group (P < 0.05, Table 2). The gene discussed is POMC; the disease is Hydrocephalus.