The PPI network of the intersection target of lotus leaf and obesity shows that protein kinase B1 (Akt1), interleukin 6 (IL6), tumor necrosis protein p53 (TP 53), caspase 3 (CASP3), JUN protein (JUN), myeloma virus oncogene homolog (MYC), epidermal growth factor receptor (EGFR), epidermal growth factor (EGF), and mitogen-activated protein kinase 8 (MAPK8) interact with multiple compounds and have high degrees and play a key role in the network diagram. The gene discussed is AKT1; the disease is obesity due to melanocortin 4 receptor deficiency.