Trinh et al. and Saengboonmee et al. [3, 23] studies showed that metformin exposure significantly reduced cancer cell proliferation, migration, and invasion [9], possibly involving the signal transducers and activators of the transcription 3(STAT3) pathway and nuclear factor-kappa B (NF-κB) pathway and reversal of EMT marker expression. Here, STAT3 is linked to cancer.