In the analysis, we found for the first time that the expression of CHRNB2 was significantly reduced only in the TP53 mutation group of gastric cancer patients, and the mutation of tumor suppressor gene TP53 may be involved in the regulation of mRNA expression in CCDC69, RASSF2, CHRNB2, ARMC9, and RPN1(Sartorio and Morabito, 1988; Hu et al., 2018; Wang et al., 2020). The gene discussed is CCDC69; the disease is gastric cancer.