Moreover, univariate Cox regression analysis identified five differentially expressed FRGs related to OS of HNSCC, among which FTH1, BNIP3, TRIB3, and SLC2A3 were high-risk FRGs (p < 0.001, hazard ratio [HR] > 1) and CDKN2A was low-risk FRGs (p < 0.001, hazard ratio [HR] < 1) (Figure 1C). Here, TRIB3 is linked to head and neck squamous cell carcinoma.