BNIP3 and head and neck squamous cell carcinoma: Meanwhile, although both BNIP3 and TRIB3 are found to have a strong impact on the development, progression, and prognosis of multiple cancers (Zhang and Ney, 2009; Gorbunova et al., 2020; Stefanovska et al., 2021), their roles in HNSCC are still inconclusive.