Although previous studies suggested that leptin played important roles in regulation specific-IgG antibody levels of influenza vaccine and clearance of influenza virus (Zhang et al., 2013; Frasca et al., 2020), we didn’t find significant associations between tag SNPs in LEP and LEPR and antibody response to influenza vaccine, which was in agreement with a previous report (Ovsyannikova et al., 2014). The gene discussed is LEP; the disease is influenza.