We also tested the correlations between the two survival subtypes (G2 and G1) and clinicopathological characteristics from the TCGA cohort and found that no significant differences were revealed in age, sex, tumor stage, metastasis coded, estrogen receptor status, progesterone receptor status, and histological type subgroups, instead of PAM50 subtype (Supplementary Figure S5, Supplementary Table S5). The gene discussed is ESR1; the disease is neoplasm.