PI3KCA and CDH1 are two frequently mutated genes in many cancers, including breast cancer, gastric cancer, colorectal carcinoma, and head and neck squamous cell carcinoma (Hansford et al., 2015; Millis et al., 2016; Zhang et al., 2017; An et al., 2018). This evidence concerns the gene CDH1 and head and neck squamous cell carcinoma.