GSEA showed that the altered genes in the high-risk HCC patients belonged to pathways related to DNA repair signaling, E2F target signaling, G2M checkpoint signaling, glycolysis signaling, MTORC1 signaling, MYC target signaling, and PI3K AKT MTOR signaling (Figure 5C). The gene discussed is AKT1; the disease is hepatocellular carcinoma.