DEFA1 and atherosclerosis: The top IPA canonical pathways included pathways related to inflammation and cardiometabolic function such as IL-8 Signaling (AZU1, DEFA1, MPO; p-value = 0.004) that plays a central role in angiogenesis, tumor growth and inflammation; liver X receptor/retinoid X receptor (LXR/RXR) Activation (ORM1, S100A8; p-value = 0.018) which is involved in the regulation of lipid metabolism, inflammation, and cholesterol; and Atherosclerosis Signaling (ORM1, S100A8; p-value = 0.019; Supplementary Table S4).