DACT2 and nasopharyngeal carcinoma: Although there are no studies on CDC25C methylation, previous study showed that CpG methylation of CDC25C upstream gene, disheveled binding antagonist of beta catenin 2 (DACT2), sensitized nasopharyngeal cancer cells to paclitaxel and 5-FU toxicity by suppressing β-catenin/CDC25C signaling, which indicates the methylation of CDC25C may obtain the same effect (56).