For GSVA results of 50 hallmark pathways from the MSigDB, we found that FUCA2 was associated with many cancer-promoting and immune-related pathway, including Glycolysis, PI3K AKT MTOR signaling, TGF BETA signaling, interferon alpha and interferon gamma response in pan-cancer (Supplementary Figure 2). The gene discussed is AKT1; the disease is cancer.