The level of sIL-2R in sepsis patients was positively correlated with WBC, CRP, SAA, IL-6, and APACHE II, and it was also positively correlated with CRP, SAA, IL-6, APACHE II, and the SOFA score in the infection group, indicating that the level of sIL-2R could better reflect the indicators related to inflammation. The gene discussed is IL6; the disease is infection.