The downregulated proteins in sepsis have been implicated in oxidative phosphorylation and the Krebs cycle (ATP5C1, DLST, ETFB, NDUFA11 NDUFA2, NDUFS7, NDUFS8, PDK3, PDP1, PDPR, RXRA, SUCLG2, TACO1, and UQCRQ), β-oxidation of fatty acids (ACADM, DECR1, PCCA, and PCCB), the related interferon signaling pathway (EIF2AK2, EIF4A3, EIF4E2, HLA-DPA1, HLA-DQA2, HLA-DRA, HLA-DRB1, IFIT1, MX1, NUP35, OAS3, PSMB8, and UBE2L6), and MHC II antigen presentation pathway (CD74, CTSH, DCTN3, DYNC1LI2, HLA-DMA, HLA-DMB, HLA- DPA1, HLA-DQA2, HLA-DRA, HLA-DRB1, KIF2A, and OSBPL1A). This evidence concerns the gene HLA-DRB1 and Sepsis.