These proteins were involved in acute phase response (e.g., C-reactive protein, lipopolysaccharide binding-protein, α-1-antichymotrypsin, and transthyretin [TTR]), coagulation pathway (e.g., fibrinogen α chain, fibrinogen β chain, fibrinogen γ chain, and VWF), lipid metabolism (e.g., apolipoprotein B-100 [Apo B100], Apo C, and Apo E), atherosclerosis signaling (e.g., Apo B-100, Apo C, Apo E), and NO and ROS production (e.g., lysozyme C, and clusterin). The gene discussed is APOE; the disease is atherosclerosis.