COL1A1, COL1A2, and COL3A1 expressed by fibroblasts interacted with cancer cells by ITGA2, DDR1, and ITGB1. Studies have shown that ITGA2, DDR1, and ITGB1 were strongly correlated with GC genesis, development, and metastasis (73–76). This evidence concerns the gene ITGB1 and gastric cancer.