These genes were enriched in the immune-related signaling pathways, such as the nucleotide-binding oligomerization domain (NOD)-like receptor signaling pathway, systemic lupus erythematosus, cytokine and cytokine receptor interaction, Th17 cell differentiation signaling pathway, janus kinase (JAK)- signal transducer and activator of transcription (STAT) signaling pathway, Th1 and Th2 cell differentiation, the forkhead box O signaling pathway, and IBD signaling pathway. The gene discussed is SOAT1; the disease is systemic lupus erythematosus.