TRAF3 and B-cell non-Hodgkin lymphoma: Paradoxically, transgenic overexpression of TRAF3 in B cells promotes B cell differentiation and results in plasmacytosis and autoimmunity in mice (26), while double transgenic overexpression of both TRAF3 and BCL-2 in B cells leads to the development of multiple classes of mature non-Hodgkin B cell lymphomas in mice (27).