Previously, forward genetics analyses revealed that Kramnik mice have a susceptible allele of super susceptibility to tuberculosis (sst1) locus on mouse chromosome 1, unlike C57BL/6 counterparts which harbor the resistant allele (63) Sp140 gene was recently identified to confer resistance to C57BL/6 mouse and it is found to negatively regulate Type I IFN responses (64). The gene discussed is SP140; the disease is tuberculosis.