More specifically, in a review by Stolarczyke and Scholte examining chronic obstructive pulmonary disease and cystic fibrosis, extensive evidence was found linking hyperactivity of the EGFR/ADAM17 signaling axis to ADAM17-cleavage of amphiregulin, an EGFR ligand (94). The gene discussed is ADAM17; the disease is chronic obstructive pulmonary disease.